2,6-Pyridine Dicarboxylic Acid (Dipicolinic Acid)


Dipicolinic Acid, 2,6-Pyridinedicarboxylic Acid, DPA; DPAc; PDC

Technical Data

CAS Number: 499-83-2
Molecular Formula: C7H5NO4
Molecular Weight: 167.12
Beilstein Registry Number: 131629
EC Number: 207-894-3

FabriChem Specifications

AppearanceWhite or Off-White Crystalline Powder
Solubility0.25 gm in 10 ml of 95% ethanol soluble
Melting Point238.0° to 252.0° C
Water Content0.50% w/w Max.
Sulfated Ash0.10% w/w Max.
Heavy Metals:
Chromium10 ppm Max.
Iron50 ppm Max.
Assay99.0% Min.
(w/w dried substance)

Molecular Structure



Dipicolinic Acid is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores. Dipicolinic acid forms a complex with calcium ions within the endospore core. This complex binds free water molecules, causing dehydration of the spore. As a result, the heat resistance of macromolecules within the core increases. The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA. It is also used to prepare transition metal complexes for ion chromatography.