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EPPS; 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid,
4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid,
N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid),
3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic acid

Technical Data

CAS Number: 16052-06-5
Molecular Formula: C9H20N2O4S
Molecular Weight: 252.33
Beilstein Registry Number: 3957385
EC Number: 240-198-8

FabriChem Specifications

AppearanceWhite crystalline powders
Assay99 ± 1 %
pH (0.1 M in water, 25°C)5.0 ~ 6.5
pKa (25°C)8.0 ± 0.2
(0.1M in water, 20°)
Complete, colorless

Molecular Structure



HEPPS [4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid] (aka EPPS) is one of the known buffering agents used for biochemical and biological research. These buffering agents are now collectively referred to as “Good’s Buffers”. Good’s Buffers are important tools used in modern biological laboratories for a variety of their properties, including but not limited to being zwitterionic (aka hybrid or dipolar) compounds.