Progesterone USP



Technical Data

CAS Number: 57-83-0
Molecular Formula: C21H30O2
Molecular Weight: 314.46
Beilstein Registry Number: 1915950
EC Number: 200-350-6

FabriChem Specifications

AppearanceWhite or almost white crystalline powder
SolubilityPractically insoluble in water, freely soluble in ethanol, sparingly soluble in acetone and in fatty oils
Melting Range126° – 131° C
Specific Rotation+175° to +183°
Identification A
Identification B
+175° to +183°
IR: Reference to standard spectrum
UV: Reference to standard spectrum
Loss on Drying0.5% Max.
Assay97.0% - 103.0%
Particle SizeTo be reported
Residual SolventsMeets USP <467> requirements

Molecular Structure


Progesterone, also known as P4, is an endogenous steroid hormone, produced by the corpus luteum. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body. Progesterone is also a crucial metabolic intermediate in the production of other endogenous steroids, and plays an important role in brain function as a neurosteroid.

In cosmetic applications, when properly formulated, topical progesterone can slow certain age-related changes to skin. Most notably, it seems to positively impact skin’s elasticity. For this reason, Progesterone is used in anti-aging creams.